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Domain > increlexhcp.com
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DNS Resolutions
Date
IP Address
2021-01-13
13.249.62.24
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ClassC
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2021-01-13
13.249.62.35
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ClassC
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2026-02-09
141.193.213.10
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ClassC
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Port 443
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0.000186373H6.01067V5.65704L5.01188 5.66588L5.01188 1.70608Z fillwhite>/path>/svg> /span> span classelementor-button-text>Referral form/span> /span> /a> /div> div classelementor-element elementor-element-714de27 header-list-btn for-open-popup elementor-widget elementor-widget-button data-id714de27 data-element_typewidget data-widget_typebutton.default> a classelementor-button elementor-size-sm rolebutton> span classelementor-button-content-wrapper> span classelementor-button-icon> svg xmlnshttp://www.w3.org/2000/svg width7 height7 viewBox0 0 7 7 fillnone>path dM5.01188 1.70608L0.707371 6.01059L0.000264148 5.30349L4.30478 0.998975L0.344979 0.998975L0.353818 0.000186373H6.01067V5.65704L5.01188 5.66588L5.01188 1.70608Z fillwhite>/path>/svg> /span> span classelementor-button-text>Important safety information/span> /span> /a> /div> div classelementor-element elementor-element-5ac8ffb header-list-btn elementor-widget elementor-widget-button data-id5ac8ffb data-element_typewidget 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354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z\"><\/path><\/svg>","library":"fa-solid"}} data-widget_typenav-menu.default> nav aria-labelMenu classelementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-none> ul idmenu-1-a81f2f7 classelementor-nav-menu sm-vertical>li classmenu-item menu-item-type-post_type menu-item-object-page menu-item-461>a hrefhttps://increlexhcp.com/diagnosing-spigfd/ classelementor-item>Diagnosing br> SPIGFD/a>/li>li classmenu-item menu-item-type-post_type menu-item-object-page menu-item-462>a hrefhttps://increlexhcp.com/understanding-spigfd/ classelementor-item>Understanding br> SPIGFD/a>/li>li classmenu-item menu-item-type-post_type menu-item-object-page menu-item-580>a hrefhttps://increlexhcp.com/increlex/ classelementor-item>INCRELEXsup>®/sup>/a>/li>li classmenu-item menu-item-type-post_type menu-item-object-page menu-item-460>a hrefhttps://increlexhcp.com/healthcare-provider-resources/ 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elementor-size-default>This site is intended for USbr> healthcare professionals./p> /div> /div> div classelementor-element elementor-element-839a1f5 main-btn elementor-align-right elementor-widget elementor-widget-button data-id839a1f5 data-element_typewidget data-widget_typebutton.default> a classelementor-button elementor-button-link elementor-size-sm href#elementor-action%3Aaction%3Dpopup%3Aopen%26settings%3DeyJpZCI6IjY0NyIsInRvZ2dsZSI6ZmFsc2V9> span classelementor-button-content-wrapper> span classelementor-button-icon> svg xmlnshttp://www.w3.org/2000/svg width14 height14 viewBox0 0 14 14 fillnone>path dM10.1458 7.5L0 7.5L0 5.83333L10.1458 5.83333L5.47917 1.16667L6.66667 0L13.3333 6.66667L6.66667 13.3333L5.47917 12.1667L10.1458 7.5Z fillwhite>/path>/svg> /span> span classelementor-button-text>Patient site/span> /span> /a> /div> /div> /div> /div> /div> /div> /div> /header> main idcontent classsite-main post-46 page type-page status-publish hentry> div classpage-content> div data-elementor-typewp-page data-elementor-id46 classelementor elementor-46 data-elementor-post-typepage> section classelementor-element elementor-element-327b27b e-con-full sticky-bg e-flex e-con e-parent data-id327b27b data-element_typecontainer data-settings{"position":"fixed"}> div classelementor-element elementor-element-db7d30f e-con-full elementor-hidden-laptop elementor-hidden-tablet elementor-hidden-mobile_extra elementor-hidden-mobile e-flex e-con e-child data-iddb7d30f data-element_typecontainer> div classelementor-element elementor-element-b87ec2a stick-img1 elementor-widget elementor-widget-image data-idb87ec2a data-element_typewidget data-widget_typeimage.default> img decodingasync width1748 height1465 srchttps://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop.png classattachment-full size-full wp-image-516 alt srcsethttps://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop.png 1748w, 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srcsethttps://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop2.png 1222w, https://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop2-250x300.png 250w, https://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop2-854x1024.png 854w, https://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop2-768x921.png 768w sizes(max-width: 1222px) 100vw, 1222px /> /div> /div> div classelementor-element elementor-element-58fbba5 e-con-full elementor-hidden-desktop elementor-hidden-laptop elementor-hidden-tablet elementor-hidden-mobile e-flex e-con e-child data-id58fbba5 data-element_typecontainer> div classelementor-element elementor-element-9b52ce8 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-laptop elementor-hidden-mobile stick-img3 elementor-widget elementor-widget-image data-id9b52ce8 data-element_typewidget data-widget_typeimage.default> img loadinglazy decodingasync width1500 height1007 srchttps://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop4.png classattachment-full size-full wp-image-514 alt srcsethttps://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop4.png 1500w, https://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop4-300x201.png 300w, https://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop4-1024x687.png 1024w, https://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop4-768x516.png 768w sizes(max-width: 1500px) 100vw, 1500px /> /div> /div> div classelementor-element elementor-element-d14dba2 e-con-full elementor-hidden-desktop elementor-hidden-laptop elementor-hidden-tablet elementor-hidden-mobile_extra e-flex e-con e-child data-idd14dba2 data-element_typecontainer> div classelementor-element elementor-element-19308ea stick-img4 elementor-widget elementor-widget-image data-id19308ea data-element_typewidget data-widget_typeimage.default> img loadinglazy decodingasync width750 height1007 srchttps://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop5.png classattachment-full size-full wp-image-513 alt srcsethttps://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop5.png 750w, https://increlexhcp.com/wp-content/uploads/2025/11/Background-Home-desktop5-223x300.png 223w sizes(max-width: 750px) 100vw, 750px /> /div> /div> /section> div classelementor-element elementor-element-040283e e-con-full page-wrapper e-flex e-con e-parent data-id040283e data-element_typecontainer> section classelementor-element elementor-element-d9576a8 e-con-full e-flex e-con e-child data-idd9576a8 data-element_typecontainer> div classelementor-element elementor-element-297805d e-flex e-con-boxed e-con e-child data-id297805d data-element_typecontainer> div classe-con-inner> div classelementor-element elementor-element-1afca5d e-con-full e-flex e-con e-child data-id1afca5d data-element_typecontainer> div classelementor-element elementor-element-5e82038 e-con-full e-flex e-con e-child data-id5e82038 data-element_typecontainer> div classelementor-element elementor-element-c05085a e-con-full e-flex e-con e-child data-idc05085a data-element_typecontainer> div classelementor-element elementor-element-5a8bf77 elementor-widget elementor-widget-heading data-id5a8bf77 data-element_typewidget data-widget_typeheading.default> p classelementor-heading-title elementor-size-default>For patients with severe primary IGF-1 deficiency (SPIGFD)/p> /div> div classelementor-element elementor-element-c50d6d4 elementor-widget elementor-widget-heading data-idc50d6d4 data-element_typewidget data-widget_typeheading.default> h1 classelementor-heading-title elementor-size-default>INCRELEXsup>®/sup> delivers what these patients are missing: IGF-1/h1> /div> /div> div classelementor-element elementor-element-f2061cc e-con-full e-flex e-con e-child data-idf2061cc data-element_typecontainer> div classelementor-element elementor-element-f85d950 elementor-widget elementor-widget-text-editor data-idf85d950 data-element_typewidget data-widget_typetext-editor.default> INCRELEXsup>®/sup> (mecasermin) is indicated for the treatment of growth failure in pediatric patients aged 2 years and older with severe primary IGF-1 deficiency* (IGFD), or with hormone (GH) gene deletion who have developed neutralizing antibodies to GH. sup>1/sup>br>INCRELEX® is not a substitute to GH for approved GH indications. /div> div classelementor-element elementor-element-735906d elementor-widget elementor-widget-text-editor data-id735906d data-element_typewidget data-widget_typetext-editor.default> p>*Severe primary IGF-1 deficiency (IGFD) is defined by height standard deviation score ≤ -3.0 and basal IGF-1 standard deviation score ≤ -3.0 and normal or elevated GH./p> /div> div classelementor-element elementor-element-4b51522 elementor-widget elementor-widget-text-editor data-id4b51522 data-element_typewidget data-widget_typetext-editor.default> Please see Indication and Important Safety Information below. /div> /div> div classelementor-element elementor-element-8383511 main-btn elementor-widget elementor-widget-button data-id8383511 data-element_typewidget data-widget_typebutton.default> a classelementor-button elementor-button-link elementor-size-sm hrefhttps://increlexhcp.com/increlex/> span classelementor-button-content-wrapper> span classelementor-button-icon> svg xmlnshttp://www.w3.org/2000/svg width14 height14 viewBox0 0 14 14 fillnone>path dM10.1458 7.5L0 7.5L0 5.83333L10.1458 5.83333L5.47917 1.16667L6.66667 0L13.3333 6.66667L6.66667 13.3333L5.47917 12.1667L10.1458 7.5Z fillwhite>/path>/svg> /span> span classelementor-button-text>Learn more/span> /span> /a> /div> /div> div classelementor-element elementor-element-59db5f9 e-con-full e-flex e-con e-child data-id59db5f9 data-element_typecontainer> div classelementor-element elementor-element-8d8de86 elementor-widget elementor-widget-image data-id8d8de86 data-element_typewidget data-widget_typeimage.default> img loadinglazy decodingasync width1642 height1339 srchttps://increlexhcp.com/wp-content/uploads/2025/11/banner-img.png classattachment-full size-full wp-image-454 alt srcsethttps://increlexhcp.com/wp-content/uploads/2025/11/banner-img.png 1642w, https://increlexhcp.com/wp-content/uploads/2025/11/banner-img-300x245.png 300w, https://increlexhcp.com/wp-content/uploads/2025/11/banner-img-1024x835.png 1024w, https://increlexhcp.com/wp-content/uploads/2025/11/banner-img-768x626.png 768w, https://increlexhcp.com/wp-content/uploads/2025/11/banner-img-1536x1253.png 1536w sizes(max-width: 1642px) 100vw, 1642px /> /div> div classelementor-element elementor-element-8b627bb e-con-full e-flex e-con e-child data-id8b627bb data-element_typecontainer> div classelementor-element elementor-element-d609204 e-con-full e-flex e-con e-child data-idd609204 data-element_typecontainer> div classelementor-element elementor-element-e0e76ed elementor-widget elementor-widget-heading data-ide0e76ed data-element_typewidget data-widget_typeheading.default> p classelementor-heading-title elementor-size-default>Age 10: 3’ 11”/p> /div> div classelementor-element elementor-element-748da99 elementor-widget elementor-widget-heading data-id748da99 data-element_typewidget data-widget_typeheading.default> p classelementor-heading-title elementor-size-default>Age 18: 4’ 10.5”/p> /div> /div> div classelementor-element elementor-element-94005be elementor-widget__width-initial elementor-widget elementor-widget-heading data-id94005be data-element_typewidget data-widget_typeheading.default> p classelementor-heading-title elementor-size-default>Olive, a former INCRELEX patient/p> /div> /div> /div> /div> /div> /div> /section> section classelementor-element elementor-element-a05c243 e-con-full e-flex e-con e-child data-ida05c243 data-element_typecontainer> div classelementor-element elementor-element-270bbd9 e-flex e-con-boxed e-con e-child data-id270bbd9 data-element_typecontainer> div classe-con-inner> div classelementor-element elementor-element-06f75c8 e-con-full e-flex e-con e-child data-id06f75c8 data-element_typecontainer> div classelementor-element elementor-element-6fbfc98 e-con-full e-flex e-con e-child data-id6fbfc98 data-element_typecontainer> a classelementor-element elementor-element-b96a8ad e-con-full hero-bottom-box e-flex e-con e-child data-idb96a8ad data-element_typecontainer data-settings{"background_background":"classic"} hrefhttps://increlexhcp.com/understanding-spigfd/> div classelementor-element elementor-element-5db277f e-con-full e-flex e-con e-child data-id5db277f data-element_typecontainer> div classelementor-element elementor-element-b1588d3 elementor-widget__width-initial elementor-widget-mobile__width-initial elementor-widget elementor-widget-heading data-idb1588d3 data-element_typewidget data-widget_typeheading.default> h3 classelementor-heading-title elementor-size-default>Understanding SPIGFD/h3> /div> div classelementor-element elementor-element-963760a box-icon-hover elementor-widget elementor-widget-image data-id963760a data-element_typewidget data-widget_typeimage.default> img loadinglazy decodingasync width16 height16 srchttps://increlexhcp.com/wp-content/uploads/2025/11/icon-3.svg classattachment-full size-full wp-image-123 alt /> /div> /div> div classelementor-element elementor-element-4e001f2 elementor-widget elementor-widget-text-editor data-id4e001f2 data-element_typewidget data-widget_typetext-editor.default> p>Learn about SPIGFD and what differentiates it from growth hormone deficiency (GHD)./p> /div> /a> a classelementor-element elementor-element-6b0318f e-con-full hero-bottom-box e-flex e-con e-child data-id6b0318f data-element_typecontainer data-settings{"background_background":"classic"} hrefhttps://increlexhcp.com/diagnosing-spigfd/> div classelementor-element elementor-element-b7f6c22 e-con-full e-flex e-con e-child data-idb7f6c22 data-element_typecontainer> div classelementor-element elementor-element-dbaa600 elementor-widget__width-initial elementor-widget-mobile__width-initial elementor-widget elementor-widget-heading data-iddbaa600 data-element_typewidget data-widget_typeheading.default> h3 classelementor-heading-title elementor-size-default>SPIGFD diagnosis/h3> /div> div classelementor-element elementor-element-adb25f8 box-icon-hover elementor-widget elementor-widget-image data-idadb25f8 data-element_typewidget data-widget_typeimage.default> img loadinglazy decodingasync width16 height16 srchttps://increlexhcp.com/wp-content/uploads/2025/11/icon-3.svg classattachment-full size-full wp-image-123 alt /> /div> /div> div classelementor-element elementor-element-02dbbae elementor-widget elementor-widget-text-editor data-id02dbbae data-element_typewidget data-widget_typetext-editor.default> p>Information on testing for severe IGF-1 deficiency and distinguishing it from GHD./p> /div> /a> a classelementor-element elementor-element-7d83e45 e-con-full hero-bottom-box e-flex e-con e-child data-id7d83e45 data-element_typecontainer data-settings{"background_background":"classic"} hrefhttps://increlexhcp.com/increlex/> div classelementor-element elementor-element-8845e34 e-con-full e-flex e-con e-child data-id8845e34 data-element_typecontainer> div classelementor-element elementor-element-aa31d2b elementor-widget__width-initial elementor-widget-mobile__width-initial elementor-widget elementor-widget-heading data-idaa31d2b data-element_typewidget data-widget_typeheading.default> h3 classelementor-heading-title elementor-size-default>INCRELEXsup>® /sup>for SPIGFD/h3> /div> div classelementor-element elementor-element-4b5f1ad box-icon-hover elementor-widget elementor-widget-image data-id4b5f1ad data-element_typewidget data-widget_typeimage.default> img loadinglazy decodingasync width16 height16 srchttps://increlexhcp.com/wp-content/uploads/2025/11/icon-3.svg classattachment-full size-full wp-image-123 alt /> /div> /div> div classelementor-element elementor-element-8129bcc elementor-widget elementor-widget-text-editor data-id8129bcc data-element_typewidget data-widget_typetext-editor.default> INCRELEX® is the only FDA-approved treatment in pediatric patients 2 years of age and older for growth failure due to SPIGFD.sup>1,2/sup> /div> /a> /div> /div> /div> /div> /section> section classelementor-element elementor-element-d1c04c0 e-con-full e-flex e-con e-child data-idd1c04c0 data-element_typecontainer> div classelementor-element elementor-element-d50ea61 e-flex e-con-boxed e-con e-child data-idd50ea61 data-element_typecontainer> div classe-con-inner> div classelementor-element elementor-element-2703730 e-con-full e-flex e-con e-child data-id2703730 data-element_typecontainer> div classelementor-element elementor-element-82c7315 elementor-widget elementor-widget-heading data-id82c7315 data-element_typewidget data-widget_typeheading.default> p classelementor-heading-title elementor-size-default>A patient’s journey/p> /div> div classelementor-element elementor-element-c2cf18c elementor-widget elementor-widget-heading data-idc2cf18c data-element_typewidget data-widget_typeheading.default> h1 classelementor-heading-title elementor-size-default>Olive’s story/h1> /div> /div> div classelementor-element elementor-element-19885e2 e-con-full e-flex e-con e-child data-id19885e2 data-element_typecontainer> div classelementor-element elementor-element-269fe25 elementor-widget elementor-widget-video data-id269fe25 data-element_typewidget data-settings{"video_type":"vimeo"} data-widget_typevideo.default> div classelementor-wrapper elementor-open-inline> iframe classelementor-video-iframe allowfullscreen allowclipboard-write titlevimeo Video Player srchttps://player.vimeo.com/video/1109577803?color&autopause0&loop0&muted0&title0&portrait0&byline0#t>/iframe> /div> /div> /div> div classelementor-element elementor-element-d8800ba main-btn elementor-align-center elementor-widget elementor-widget-button data-idd8800ba data-element_typewidget data-widget_typebutton.default> a classelementor-button elementor-button-link elementor-size-sm hrefhttps://www.youtube.com/@IncrelexRx> span classelementor-button-content-wrapper> span classelementor-button-icon> svg xmlnshttp://www.w3.org/2000/svg width14 height14 viewBox0 0 14 14 fillnone>path dM10.1458 7.5L0 7.5L0 5.83333L10.1458 5.83333L5.47917 1.16667L6.66667 0L13.3333 6.66667L6.66667 13.3333L5.47917 12.1667L10.1458 7.5Z fillwhite>/path>/svg> /span> span classelementor-button-text>Visit Youtube for more videos/span> /span> /a> /div> /div> /div> /section> section classelementor-element elementor-element-2f71741 e-con-full healthcare-main e-flex e-con e-child data-id2f71741 data-element_typecontainer> div classelementor-element elementor-element-dd30cf2 e-flex e-con-boxed e-con e-child data-iddd30cf2 data-element_typecontainer> div classe-con-inner> div classelementor-element elementor-element-c7cfc86 e-con-full e-flex e-con e-child data-idc7cfc86 data-element_typecontainer> div classelementor-element elementor-element-c891321 e-con-full e-flex e-con e-child data-idc891321 data-element_typecontainer> div classelementor-element elementor-element-d03aaaa elementor-widget elementor-widget-image data-idd03aaaa data-element_typewidget data-widget_typeimage.default> img loadinglazy decodingasync width513 height489 srchttps://increlexhcp.com/wp-content/uploads/2025/11/Image-1.png classattachment-full size-full wp-image-135 alt srcsethttps://increlexhcp.com/wp-content/uploads/2025/11/Image-1.png 513w, https://increlexhcp.com/wp-content/uploads/2025/11/Image-1-300x286.png 300w sizes(max-width: 513px) 100vw, 513px /> /div> /div> div classelementor-element elementor-element-5bb9fef e-con-full e-flex e-con e-child data-id5bb9fef data-element_typecontainer data-settings{"background_background":"classic"}> div classelementor-element elementor-element-e1ea9c9 e-con-full e-flex e-con e-child data-ide1ea9c9 data-element_typecontainer data-settings{"background_background":"classic"}> div classelementor-element elementor-element-7e2628c elementor-widget elementor-widget-heading data-id7e2628c data-element_typewidget data-widget_typeheading.default> h2 classelementor-heading-title elementor-size-default>Healthcare Provider Resources/h2> /div> div classelementor-element elementor-element-fad8b3b elementor-widget elementor-widget-text-editor data-idfad8b3b data-element_typewidget data-widget_typetext-editor.default> Visual aids and resources to help become more knowledgeable about INCRELEXsup>®/sup>, including patient education and support information. /div> div classelementor-element elementor-element-2752378 main-btn elementor-widget elementor-widget-button data-id2752378 data-element_typewidget data-widget_typebutton.default> a classelementor-button elementor-button-link elementor-size-sm hrefhttps://increlexhcp.com/healthcare-provider-resources/> span classelementor-button-content-wrapper> span classelementor-button-icon> svg xmlnshttp://www.w3.org/2000/svg width14 height14 viewBox0 0 14 14 fillnone>path dM10.1458 7.5L0 7.5L0 5.83333L10.1458 5.83333L5.47917 1.16667L6.66667 0L13.3333 6.66667L6.66667 13.3333L5.47917 12.1667L10.1458 7.5Z fillwhite>/path>/svg> /span> span classelementor-button-text>Read More/span> /span> /a> /div> /div> div classelementor-element elementor-element-a6da72b e-con-full e-flex e-con e-child data-ida6da72b data-element_typecontainer> div classelementor-element elementor-element-a7ed8d1 healthcare-bottom-line elementor-widget elementor-widget-heading data-ida7ed8d1 data-element_typewidget data-widget_typeheading.default> p classelementor-heading-title elementor-size-default>Olive, a former INCRELEX® patient, at age 18./p> /div> /div> /div> /div> /div> /div> /section> div classelementor-element elementor-element-e076dbb e-con-full content-section-bottom e-flex e-con e-child data-ide076dbb data-element_typecontainer data-settings{"background_background":"gradient"}> div classelementor-element elementor-element-06f0fd6 e-flex e-con-boxed e-con e-child data-id06f0fd6 data-element_typecontainer> div classe-con-inner> div classelementor-element elementor-element-78a34b3 e-con-full e-flex e-con e-child data-id78a34b3 data-element_typecontainer> div classelementor-element elementor-element-0c18ad3 elementor-widget elementor-widget-image data-id0c18ad3 data-element_typewidget data-widget_typeimage.default> img loadinglazy decodingasync width47 height47 srchttps://increlexhcp.com/wp-content/uploads/2025/11/Favicon.svg classattachment-full size-full wp-image-24 alt /> /div> /div> div classelementor-element elementor-element-1399bd3 e-con-full e-flex e-con e-child data-id1399bd3 data-element_typecontainer> div classelementor-element elementor-element-f8b803a elementor-widget__width-initial elementor-widget elementor-widget-heading data-idf8b803a data-element_typewidget data-widget_typeheading.default> h2 classelementor-heading-title elementor-size-default>Indication and important safety information/h2> /div> div classelementor-element elementor-element-24e08b3 elementor-widget elementor-widget-text-editor data-id24e08b3 data-element_typewidget data-widget_typetext-editor.default> p>INCRELEX® (mecasermin) is indicated for the treatment of growth failure in pediatric patients aged 2 years and older with severe primary IGF-1 deficiency* (IGFD), or with hormone (GH) gene deletion who have developed neutralizing antibodies to GH./p> /div> div classelementor-element elementor-element-32a5fff elementor-widget elementor-widget-text-editor data-id32a5fff data-element_typewidget data-widget_typetext-editor.default> p>Limitations of use: INCRELEX is not a substitute to GH for approved GH indications. INCRELEX is not indicated for use in patients with secondary forms of IGFD, such as GH deficiency, malnutrition, hypothyroidism, or chronic treatment with pharmacologic doses of anti-inflammatory steroids./p> /div> div classelementor-element elementor-element-5556326 elementor-widget elementor-widget-text-editor data-id5556326 data-element_typewidget data-widget_typetext-editor.default> *Severe primary IGF-1 deficiency (IGFD) is defined by height standard deviation score ≤ -3.0 and basal IGF-1 standard deviation score ≤ -3.0 and normal or elevated GH. /div> /div> div classelementor-element elementor-element-4f727d8 e-con-full e-flex e-con e-child data-id4f727d8 data-element_typecontainer> div classelementor-element elementor-element-ad7a9e1 elementor-widget__width-initial elementor-widget elementor-widget-heading data-idad7a9e1 data-element_typewidget data-widget_typeheading.default> h2 classelementor-heading-title elementor-size-default>Important safety information/h2> /div> div classelementor-element elementor-element-e68cb00 elementor-widget elementor-widget-text-editor data-ide68cb00 data-element_typewidget data-widget_typetext-editor.default> h3>Contraindications/h3>ul> li>strong>Hypersensitivity:/strong> to mecasermin (rhIGF-1), any of the inactive ingredients in INCRELEX, or who have experienced a severe hypersensitivity to INCRELEX. Allergic reactions have been reported, including anaphylaxis requiring hospitalization./li>li>strong>Closed Epiphyses/strong>/li> li>strong>Malignant Neoplasia/strong> in pediatric patients with malignant neoplasia or a history of malignancy./li>/ul> /div> div classelementor-element elementor-element-f1eeea8 elementor-widget elementor-widget-text-editor data-idf1eeea8 data-element_typewidget data-widget_typetext-editor.default> h3>Warning and precautions/h3>ul>li>strong>Hypoglycemia:/strong> INCRELEX should be administered 20 minutes before or after a meal or snack and should not be administered when the meal or snack is omitted. Glucose monitoring and INCRELEX dose titration are recommended until a well-tolerated dose is established and as medically indicated./li>li>strong>Intracranial Hypertension:/strong> Funduscopic examination is recommended at the initiation of and periodically during the course of therapy./li>li>strong>Lymphoid Tissue Hypertrophy:/strong> Patients should have periodic examinations to rule out potential complications./li>li>strong>Slipped Capital Femoral Epiphysis:/strong> Slipped capital femoral epiphysis may lead to osteonecrosis. Cases of slipped capital femoral epiphysis with or without osteonecrosis have been reported in pediatric patients receiving products indicated to treat growth failure and/or short stature, including INCRELEX. Carefully evaluate any pediatric patient with the onset of a limp or hip/knee pain during INCRELEX therapy./li>li>strong>Progression of Scoliosis:/strong> Patients with a history of scoliosis, treated with INCRELEX, should be monitored./li>li>strong>Malignant Neoplasia:/strong> There have been postmarketing reports of malignant neoplasia in pediatric patients who received treatment with INCRELEX. It is unknown whether there is any relationship between Increlex therapy and new occurrences of neoplasia. The tumors were observed more frequently in patients who received INCRELEX at higher than recommended doses or at doses that produced serum IGF-1 levels above the normal reference ranges for age and sex. Monitor all patients receiving INCRELEX carefully for development of neoplasms. If malignant neoplasia develops, discontinue INCRELEX treatment./li>li>strong>Risk of Serious Adverse Reactions in Infants due to Benzyl Alcohol Preserved Solution:/strong> Serious and fatal adverse reactions including “gasping syndrome” can occur in neonates and infants treated with benzyl alcohol-preserved drugs. Use of INCRELEX in infants is not recommended./li>/ul> /div> div classelementor-element elementor-element-c6bd628 elementor-widget elementor-widget-text-editor data-idc6bd628 data-element_typewidget data-widget_typetext-editor.default> h3>Adverse reactions/h3>p>Common adverse reactions include hypoglycemia, local and systemic hypersensitivity, and tonsillar hypertrophy./p>p>To report a suspected adverse event related to INCRELEX, contact Eton Pharmaceuticals, Inc. at 1-855-224-0233 or the U.S. Food and Drug Administration (FDA) at a hrefhttps://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program>span styletext-decoration: underline;>www.fda.gov/safety/Medwatch/span>/a> or call 1-800-FDA-1088./p>p>Please see a hrefhttps://increlexhcp.com/wp-content/uploads/2025/11/Increlex-Combined-Label-2178-v2.pdf target_blank relnoopener>span styletext-decoration: underline;>full Prescribing Information/span>/a> for more information./p> /div> div classelementor-element elementor-element-4abbcd8 elementor-widget elementor-widget-text-editor data-id4abbcd8 data-element_typewidget data-widget_typetext-editor.default> h3>References/h3>ol> li>INCRELEX. Package insert. Eton Pharmaceuticals, Inc; 2023./li> li>Backeljauw PF, Chernausek SD. Treatment of severe IGF-1 deficiency with recombinant human IGF-1 (mecasermin). em>Curr Med Lit Growth/em>. 2009;2sup>3/sup>:69-95./li>/ol> /div> /div> div classelementor-element elementor-element-03be3e5 e-con-full e-flex e-con e-child data-id03be3e5 data-element_typecontainer> div classelementor-element elementor-element-0b9acfd elementor-widget elementor-widget-image data-id0b9acfd data-element_typewidget data-widget_typeimage.default> img loadinglazy decodingasync width47 height47 srchttps://increlexhcp.com/wp-content/uploads/2025/11/Favicon.svg classattachment-full size-full wp-image-24 alt /> /div> /div> /div> /div> /div> section classelementor-element elementor-element-7eefea1 e-con-full sticky-indication e-flex e-con e-child data-id7eefea1 data-element_typecontainer data-settings{"background_background":"classic"}> div classelementor-element elementor-element-e646dfa e-flex e-con-boxed e-con e-child data-ide646dfa data-element_typecontainer> div classe-con-inner> div classelementor-element elementor-element-c264848 e-con-full sticky-popup-header e-flex e-con e-child data-idc264848 data-element_typecontainer> div classelementor-element elementor-element-b61d084 elementor-widget-mobile__width-initial elementor-widget elementor-widget-heading data-idb61d084 data-element_typewidget data-widget_typeheading.default> h2 classelementor-heading-title elementor-size-default>Indication and important safety information/h2> /div> div classelementor-element elementor-element-016dbca for-open-popup elementor-mobile-align-center elementor-widget elementor-widget-button data-id016dbca data-element_typewidget data-widget_typebutton.default> a classelementor-button elementor-button-link elementor-size-sm href#. idopen-popup-text> span classelementor-button-content-wrapper> span classelementor-button-icon> svg xmlnshttp://www.w3.org/2000/svg width14 height14 viewBox0 0 14 14 fillnone>path dM7.42465 13.3643L5.93973 13.3643L5.93973 7.42459L3.04332e-05 7.42459V5.93967L5.93973 5.93967L5.93973 -2.99267e-05L7.42465 -2.9421e-05L7.42465 5.93967L13.3643 5.93967V7.42459L7.42465 7.42459L7.42465 13.3643Z fill#005C83>/path>/svg> /span> span classelementor-button-text>Open/span> /span> /a> /div> /div> div classelementor-element elementor-element-94d91c7 popup-content content-section-bottom e-flex e-con-boxed e-con e-child data-id94d91c7 data-element_typecontainer> div classe-con-inner> div classelementor-element elementor-element-62cf07f e-con-full e-flex e-con e-child data-id62cf07f data-element_typecontainer> div classelementor-element elementor-element-29eb9a3 elementor-widget elementor-widget-text-editor data-id29eb9a3 data-element_typewidget data-widget_typetext-editor.default> p>INCRELEX® (mecasermin) is indicated for the treatment of growth failure in pediatric patients aged 2 years and older with severe primary IGF-1 deficiency* (IGFD), or with hormone (GH) gene deletion who have developed neutralizing antibodies to GH./p> /div> div classelementor-element elementor-element-63af7a3 elementor-widget elementor-widget-text-editor data-id63af7a3 data-element_typewidget data-widget_typetext-editor.default> p>Limitations of use: INCRELEX is not a substitute to GH for approved GH indications. INCRELEX is not indicated for use in patients with secondary forms of IGFD, such as GH deficiency, malnutrition, hypothyroidism, or chronic treatment with pharmacologic doses of anti-inflammatory steroids./p> /div> div classelementor-element elementor-element-a84384a elementor-widget elementor-widget-text-editor data-ida84384a data-element_typewidget data-widget_typetext-editor.default> p>*Severe primary IGF-1 deficiency (IGFD) is defined by height standard deviation score ≤ -3.0 and basal IGF-1 standard deviation score ≤ -3.0 and normal or elevated GH./p> /div> /div> div classelementor-element elementor-element-e830dda e-con-full e-flex e-con e-child data-ide830dda data-element_typecontainer> div classelementor-element elementor-element-28ac593 elementor-widget__width-initial elementor-widget elementor-widget-heading data-id28ac593 data-element_typewidget data-widget_typeheading.default> h2 classelementor-heading-title elementor-size-default>Important safety information/h2> /div> div classelementor-element elementor-element-06fcbd8 elementor-widget elementor-widget-text-editor data-id06fcbd8 data-element_typewidget data-widget_typetext-editor.default> h3>Contraindications/h3>ul>li>strong>Hypersensitivity:/strong> to mecasermin (rhIGF-1), any of the inactive ingredients in INCRELEX, or who have experienced a severe hypersensitivity to INCRELEX. Allergic reactions have been reported, including anaphylaxis requiring hospitalization./li>li>strong>Closed Epiphysesbr />/strong>/li>li>strong>Malignant Neoplasia/strong> in pediatric patients with malignant neoplasia or a history of malignancy./li>/ul> /div> div classelementor-element elementor-element-5c51f8e elementor-widget elementor-widget-text-editor data-id5c51f8e data-element_typewidget data-widget_typetext-editor.default> h3>Warning and precautions/h3>ul>li>strong>Hypoglycemia:/strong> INCRELEX should be administered 20 minutes before or after a meal or snack and should not be administered when the meal or snack is omitted. Glucose monitoring and INCRELEX dose titration are recommended until a well-tolerated dose is established and as medically indicated./li>li>strong>Intracranial Hypertension:/strong> Funduscopic examination is recommended at the initiation of and periodically during the course of therapy./li>li>strong>Lymphoid Tissue Hypertrophy:/strong> Patients should have periodic examinations to rule out potential complications./li>li>strong>Slipped Capital Femoral Epiphysis:/strong> Slipped capital femoral epiphysis may lead to osteonecrosis. Cases of slipped capital femoral epiphysis with or without osteonecrosis have been reported in pediatric patients receiving products indicated to treat growth failure and/or short stature, including INCRELEX. Carefully evaluate any pediatric patient with the onset of a limp or hip/knee pain during INCRELEX therapy./li>li>strong>Progression of Scoliosis:/strong> Patients with a history of scoliosis, treated with INCRELEX, should be monitored./li>li>strong>Malignant Neoplasia:/strong> There have been postmarketing reports of malignant neoplasia in pediatric patients who received treatment with INCRELEX. It is unknown whether there is any relationship between Increlex therapy and new occurrences of neoplasia. The tumors were observed more frequently in patients who received INCRELEX at higher than recommended doses or at doses that produced serum IGF-1 levels above the normal reference ranges for age and sex. Monitor all patients receiving INCRELEX carefully for development of neoplasms. If malignant neoplasia develops, discontinue INCRELEX treatment./li>li>strong>Risk of Serious Adverse Reactions in Infants due to Benzyl Alcohol Preserved Solution:/strong> Serious and fatal adverse reactions including “gasping syndrome” can occur in neonates and infants treated with benzyl alcohol-preserved drugs. Use of INCRELEX in infants is not recommended./li>/ul> /div> div classelementor-element elementor-element-f8354f4 elementor-widget elementor-widget-text-editor data-idf8354f4 data-element_typewidget data-widget_typetext-editor.default> h3>Adverse reactions/h3>p>Common adverse reactions include hypoglycemia, local and systemic hypersensitivity, and tonsillar hypertrophy./p>p>To report a suspected adverse event related to INCRELEX, contact Eton Pharmaceuticals, Inc. at 1-855-224-0233 or the U.S. Food and Drug Administration (FDA) at a hrefhttps://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program>span styletext-decoration: underline;>www.fda.gov/safety/Medwatch/span>/a> or call 1-800-FDA-1088./p>p>Please see a hrefhttps://increlexhcp.com/wp-content/uploads/2025/11/Increlex-Combined-Label-2178-v2.pdf target_blank relnoopener>span styletext-decoration: underline;>full Prescribing Information/span>/a> for more information./p> /div> div classelementor-element elementor-element-227ccb0 elementor-widget elementor-widget-text-editor data-id227ccb0 data-element_typewidget data-widget_typetext-editor.default> h3>References/h3>ol>li>INCRELEX. Package insert. Eton Pharmaceuticals, Inc; 2023./li>li>Backeljauw PF, Chernausek SD. Treatment of severe IGF-1 deficiency with recombinant human IGF-1 (mecasermin). em>Curr Med Lit Growth/em>. 2009;2sup>3/sup>:69-95./li>/ol> /div> /div> /div> /div> /div> /div> /section> /div> /div> /div> /main> footer data-elementor-typefooter data-elementor-id167 classelementor elementor-167 elementor-location-footer data-elementor-post-typeelementor_library> div classelementor-element elementor-element-24f8ee7 e-con-full e-flex e-con e-parent data-id24f8ee7 data-element_typecontainer data-settings{"background_background":"classic"}> div classelementor-element elementor-element-792549a e-flex e-con-boxed e-con e-child data-id792549a data-element_typecontainer> div classe-con-inner> div classelementor-element elementor-element-c13aba9 e-flex e-con-boxed e-con e-child data-idc13aba9 data-element_typecontainer data-settings{"background_background":"classic"}> div classe-con-inner> div classelementor-element elementor-element-8d48b48 e-con-full e-flex e-con e-child data-id8d48b48 data-element_typecontainer> div classelementor-element elementor-element-3d399be e-con-full e-flex e-con e-child data-id3d399be data-element_typecontainer> div classelementor-element elementor-element-f7226d2 elementor-widget elementor-widget-image data-idf7226d2 data-element_typewidget data-widget_typeimage.default> img width200 height100 srchttps://increlexhcp.com/wp-content/uploads/2025/11/eton_vF_0925_white-1.svg classattachment-full size-full wp-image-22 alt /> /div> div classelementor-element elementor-element-52474cc elementor-widget elementor-widget-text-editor data-id52474cc data-element_typewidget data-widget_typetext-editor.default> INCRELEXsup>®/sup> is a registered trademark of Eton Pharmaceuticals, Inc. Eton and Eton Cares are trademarks of Eton Pharmaceuticals, Inc. /div> /div> div classelementor-element elementor-element-6ae482f e-con-full e-flex e-con e-child data-id6ae482f data-element_typecontainer> div classelementor-element elementor-element-174cc07 elementor-nav-menu--dropdown-none footer-menu elementor-widget elementor-widget-nav-menu data-id174cc07 data-element_typewidget data-settings{"layout":"vertical","submenu_icon":{"value":"<svg aria-hidden\"true\" class\"e-font-icon-svg e-fas-caret-down\" viewBox\"0 0 320 512\" xmlns\"http:\/\/www.w3.org\/2000\/svg\"><path d\"M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z\"><\/path><\/svg>","library":"fa-solid"}} data-widget_typenav-menu.default> nav aria-labelMenu classelementor-nav-menu--main elementor-nav-menu__container elementor-nav-menu--layout-vertical e--pointer-none> ul idmenu-1-174cc07 classelementor-nav-menu sm-vertical>li classmenu-item 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